Trends in Prescription of Drugs for the Treatment of Dementia in Slovenia in the Period from 2008 to 2018

Authors

  • Marjetka Jelenc
  • Aleš Korošec
  • Mercedes Lovrenčič

Keywords:

dementia, drugs, prescriptions, trends

Abstract

Dementia is a clinical syndrome in mostly older people that manifests with cognitive function problems. Its consequences represent a growing health, social and economic problem in many countries. Monitoring drug prescription contributes to better management of treatment. Our aim was to evaluate changes and trends in the prescribing of drugs for the treatment of dementia in Slovenia in the period from 2008 to 2018, by gender and age groups. Therefore, we conducted a retrospective, observational study based on the data from the “Database of prescriptions for outpatients” of the Republic of Slovenia. The analysis showed that the number of prescriptions for anti-dementia drugs increased by 140% between 2008 and 2018. The most commonly prescribed drugs were acetylcholinesterase enzyme inhibitors. Outpatient prescribing increased in both men and women, and the number of recipients of at least one prescription more than doubled in the observed period. However, not all dementia patients are treated with appropriate medicines, especially at an early stage of the disease when dementia is not yet
recognized or diagnosed.

References

Blejc, U. (2018). Ob demenci ne smemo izgubljati časa. Pharmonia, 42.

Cummings, J. (2017). Disease modification and neuroprotection in neurodegenerative disorders. Translational Neurodegeneration, 6, p. 25.

Cummings, J., Morstorf, T. and Lee, G. (2016). Alzheimer's disease drug development pipeline: 2016. Alzheimers Dement, 2, pp. 222–223.

Databases Act in the area of healthcare (2000). Zakon o zbirkah podatkov s področja zdravstvenega varstva (2000). Uradni list Republike Slovenije, št. 65. Retrieved on 01/21/2020 from the Internet: http://www.pisrs.si/Pis.web/pregledPredpisa?id=ZAKO1419.

Donegan, K., Fox, N., Black, N., Livingston, G., Banerjee, S. and Burns, A. (2017). Trends in diagnosis and treatment for people with dementia in the UK from 2005 to 2015: a longitudinal retrospective cohort study. Lancet Public Health, 2, No. 3, e149-e156.

Gregorič Kramberger, M. (2017). Demenca je izziv sodobne družbe. Farmacevtski vestnik, 68, No 2, pp. 123–128.

Jelenc, M. (2013). Characteristics of prescriptions of medicines for patients with the highest number of prescriptions in Slovenia in 2011 (Diploma thesis). Ljubljana: Medical Faculty.

Jelenc, M., Kostnapfel, T. and Eržen, I. (2018). Naraščanje porabe zdravil za zdravljenje demence v Sloveniji. In: Kregar Velikonja, N. (ed.). Celostna obravnava pacienta. Novo Mesto: Univerza v Novem mestu, Fakulteta za zdravstvene vede, pp. 186–190.

Kogoj, A. (2011). Vedenjske in psihične spremembe pri demenci. Celje: Visoka zdravstvena šola.

Kostnapfel Rihtar, T. and Korošec, A. (2014). The importance of monitoring the use of medicines in the health care system. In: Consumption of outpatient prescribed drugs in 2014 in Slovenia. Ljubljana: NIPH.

Ministry of Health of the Republic of Slovenia. Ministrstvo za zdravje RS. (2016). Dementia management strategy in Slovenia until 2020. Strategija obvladovanja demence v Sloveniji do leta 2020. Retrieved on 01/11/2020 from the Internet: https://www.google.si/

search?q=strategija+obvladovanja+demence+v+sloveniji+do+leta+2020.

Pankevich, D. E., Altevogt, B. M., Dunlop, J., Gage, F. H. and Hyman, S. E. (2014). Improving and accelerating drug development for nervous system disorders. Neuron, 84, pp. 546–453.

Satizabal, C. L., Beiser, A. S., Chouraki, V. et al. (2016). Incidence of dementia over three decades in the Framingham Heart Study. N Engl J Med, 374, pp. 523–532.

Sommerlad, A., Perera, G., Singh - Manoux, A., Lewis, G., Stewart, R. and Livingston, G. (2018). Accuracy of general hospital dementia diagnoses in England: Sensitivity, specificity, and predictors of diagnostic accuracy 2008–2016. Alzheimer’s & Dementia, 14, pp. 933–943.

WHO Collaborating Centre for Drug Statistics Methodology. Definition and General Considerations. Norwegian Institute of Public Health, Oslo, Norway. Retrieved on 01/21/2020 from the Internet: https://www.whocc.no/ddd/definition_and_general_considera/.

Downloads

Published

2022-04-17

Issue

Section

Articles

How to Cite

Trends in Prescription of Drugs for the Treatment of Dementia in Slovenia in the Period from 2008 to 2018. (2022). Revija Za Zdravstvene Vede, 7(1), 19-30. https://www.jhs.si/index.php/JHS/article/view/90

Most read articles by the same author(s)