Krhkost

od biološkega k bio-psiho-socialnemu razumevanju geriatričnega sindroma

Avtorji

  • Mateja Strbad
  • Milica Gregorič Kramberger

Ključne besede:

krhkost, kognitivna krhkost, (psiho)socialna krhkost, staranje, geriatrija

Povzetek

Namen prispevka je natančneje opredeliti krhkost (dinamičen proces zmanjšanja telesnega, psihološkega in/ali socialnega funkcioniranja, povezanega s staranjem). Je pogost geriatrični sindrom. Pomeni povečano ranljivost posameznika za stresorje zaradi manjše fiziološke rezerve, slabše homeostaze. V elektronski bazi podatkov PubMed smo pregledali razpoložljivo strokovno literaturo, tako izvirne znanstvene članke kot tudi sistematične in druge preglede literature ter ekspertna mnenja. V zadnjih letih se je cilj proučevanja iz zgolj telesnih vidikov krhkosti preusmeril v bolj celostno – bio-psiho-socialno obravnavo krhkih starostnikov. Zaenkrat stroka še vedno ni enotna glede samega razumevanja koncepta, saj obstajajo številne identifikacijske lestvice. Pogosta posledica krhkosti je tako slabši izid zdravljenja kot tudi slabši funkcionalni status. Vedno več je dokazov o učinkovitosti različnih intervenc, ki pozitivno vplivajo na že izraženo krhkost, kot tudi preprečujejo razvoj krhkosti pri ranljivih posameznikih.

Literatura

Bertoli, A., Valentini, A., Cianfarani, M. A., Gasbarra, E., Tarantino, U. and Federici, M. (2017). Low FT3: a possible marker of frailty in the elderly. Clin Interv Aging, 12, št. 3, str. 335–341.

Bishop, N. A., Lu, T. and Yankner, B. A. (2010). Neural mechanisms of ageing and cognitive decline. Nature, 464, št. 7288, str. 529–535.

Buckinx, F., Rolland, Y., Reginster, J. Y., Ricour, C., Petermans, J. and Bruyère, O. (2015). Burden of frailty in the elderly population: perspectives for a public health challenge. Arch Public Health, 73, št. 1, str. 19.

Carneiro, J. A., Cardoso, R. R., Durães, M. S., Guedes, M. C. A., Santos, F. L., Costa, F. M. D. idr. (2017). Frailty in the elderly: prevalence and associated factors. Rev Bras Enferm, 70, št. 4, str. 747–752.

Choutko - Joaquim, S., Tacchini - Jacquier, N., Pralong D'Alessio, G. and Verloo, H. (2019). Associations between Frailty and Delirium among Older Patients Admitted to an Emergency Department. Dement Geriatr Cogn Dis Extra, 9, št. 2, str. 236–249.

Clegg, A. and Hassan - Smith, Z. (2018). Frailty and the endocrine system. Lancet Diabetes Endocrinol, 6, št. 9, str. 743–752.

Clegg, A., Young, J., Iliffe, S., Rikkert, M. O. and Rockwood, K. (2013). Frailty in elderly people. Lancet, 381, št. 9868, str. 752–762.

Collard, R. M., Boter, H., Schoevers, R. A. and Oude Voshaar, R. C. (2012). Prevalence of frailty in community-dwelling older persons: a systematic review. J Am Geriatr Soc, 60, št. 8, str. 1487–1492.

Cruz - Jentoft, A. J. and Woo, J. (2019). Nutritional interventions to prevent and treat frailty.Curr Opin Clin Nutr Metab Care, 22, št. 3, str. 191–195.

Denfeld, Q. E., Winters - Stone, K., Mudd, J. O., Gelow, J. M., Kurdi, S. and Lee, C. S. (2017). The prevalence of frailty in heart failure: A systematic review and meta-analysis. Int J Cardiol, 236, str. 283–289.

Drubbel, I., de Wit, N. J., Bleijenberg, N., Eijkemans, R. J., Schuurmans, M. J. and Numans, M. E. (2013). Prediction of adverse health outcomes in older people using a frailty index based on routine primary care data. J Gerontol A Biol Sci Med Sci, 68, št. 3, str. 301–308.

Faller, J. W., Pereira, J. D., de Souza, S., Nampo, F. K., Orlandi, F. S. and Matumoto, S. (2019). Instruments for the detection of frailty syndrome in older adults: A systematic review. PLoS One, 14, št. 4, str. e0216166.

Freer, K. and Wallington, S. L. (2019). Social frailty: the importance of social and environmental factors in predicting frailty in older adults. Br J Community Nurs, 24, št. 10, str. 486–492.

Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J. idr. (2001). Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci, 56, št. 3, str. M146-56.

Fried, L. P., Xue, Q. L., Cappola, A. R., Ferrucci, L., Chaves, P., Varadhan, R. idr. (2009). Nonlinear Multisystem Physiological Dysregulation Associated with Frailty in Older Women: Implications for Etiology and Treatment. J Gerontol A Biol Sci Med Sci, str. 1049–1057.

Fulop, T., McElhaney, J., Pawelec, G., Cohen, A. A., Morais, J. A., Dupuis, G. idr. (2015). Frailty, Inflammation and Immunosenescence. Interdiscip Top Gerontol Geriatr, št. 41, str. 26–40.

Hamerman, D. (1999). Toward an understanding of frailty. Ann Intern Med, 130, št. 11, str. 945–950.

Handforth, C., Clegg, A., Young, C., Simpkins, S., Seymour, M. T., Selby, P. J. idr. (2015). The prevalence and outcomes of frailty in older cancer patients: a systematic review. Ann Oncol, 26, št. 6, str. 1091–1101.

Hoogendijk, E. O., Suanet, B., Dent, E., Deeg, D. J. and Aartsen, M. J. (2016). Adverse effects of frailty on social functioning in older adults: Results from the Longitudinal Aging Study Amsterdam. Maturitas, 83, str. 45–50.

Hoogendijk, E. O., Afilalo, J., Ensrud, K. E., Kowal, P., Graziano Onder, G. and Fried, L. P. (2019). Frailty: implications for clinical practice and public health. Lancet, 394, št. 10206, str. 1365–1375.

Kim, S. W., Han, H. S., Jung, H. W., Kim, K. I., Hwang, D. W., Kang, S. B. idr. (2014). Multidimensional frailty score for the prediction of postoperative mortality risk. JAMA Surg, 149, št. 7, str. 633–640.

Kojima, G. (2016b). Frailty as a predictor of hospitalisation among community-dwelling older people: a systematic review and meta-analysis. J Epidemiol Community Health, 70, št. 7, str. 722–729.

Kojima, G. (2017). Frailty as a predictor of disabilities among community-dwelling older people: a systematic review and meta-analysis. Disabil Rehabil, 39, št. 19, str. 1897–1908.

Kojima, G. (2018). Frailty as a Predictor of Nursing Home Placement Among CommunityDwelling Older Adults: A Systematic Review and Meta-analysis. J Geriatr Phys Ther, 41, št. 1, str. 42–48.

Kojima, G. (2015). Frailty as a Predictor of Future Falls Among Community-Dwelling Older People: A Systematic Review and Meta-Analysis. J Am Med Dir Assoc, 16, št. 12, str. 1027–1033.

Kojima, G. (2016a). Frailty as a predictor of fractures among community-dwelling older people: A systematic review and meta-analysis. Bone, 90, str. 116–122.

Kojima, G., Iliffe, S. and Walters, K. (2018). Frailty index as a predictor of mortality: a systematic review and meta-analysis. Age Ageing, 47, št. 2, str. 193–200.

Kojima, G., Taniguchi, Y., Iliffe, S. and Walters, K. (2016a). Frailty as a Predictor of Alzheimer Disease, Vascular Dementia, and All Dementia Among Community-Dwelling Older People: A Systematic Review and Meta-Analysis. J Am Med Dir Assoc, 17, št. 10, str. 881–888.

Kojima, G., Iliffe, S., Jivraj, S. and Walters, K. (2016b). Association between frailty and quality of life among community-dwelling older people: a systematic review and meta-analysis. J Epidemiol Community Health, 70, št. 7, str. 716–721.

Luo, X. G., Ding, J. Q. and Chen, S. D. (2010). Microglia in the aging brain: relevance to neurodegeneration. Mol Neurodegener, 5, str. 12.

Ma, L., Tang, Z., Zhang, L., Sun, F., Li, Y. and Chan, P. (2018) Prevalence of Frailty and Associated Factors in the Community-Dwelling Population of China. J Am Geriatr Soc, 66, št. 3, str. 559–564.

McAdams-DeMarco, M. A., Law, A., King, E., Orandi, B., Salter, M., Gupta, N. idr. (2015). Frailty and mortality in kidney transplant recipients. Am J Transplant, 15, št. 1, str. 149–154.

McGuigan, F. E., Bartosch, P. and Akesson, K. E. (2017). Musculoskeletal health and frailty. Best Pract Res Clin Rheumatol, 31, št. 2, str. 145–159.

Miller, D. B. and O'Callaghan, J. P. (2005). Aging, stress and the hippocampus. Ageing Res Rev, 4, št. 2, str. 123–140.

Morley, J. E. (2016). Frailty and sarcopenia in elderly. Wien Klin Wochenschr, 128, št. 7. str. 439–445.

Nascimento, C. M., Ingles, M., Salvador - Pascual, A., Cominetti, M. R., Gomez - Cabrera, M. C. and Viña, J. (2019). Sarcopenia, frailty and their prevention by exercise. Free Radic Biol Med, 132, str. 42–49.

Prenosi

Objavljeno

2022-04-17

Kako citirati

Strbad, M., & Gregorič Kramberger, M. (2022). Krhkost: od biološkega k bio-psiho-socialnemu razumevanju geriatričnega sindroma. Revija Za Zdravstvene Vede, 8(2), 108–119. Pridobljeno od https://www.jhs.si/index.php/JHS/article/view/119

Številka

Rubrike

Prispevki